HPLC method development/validation and skin diffusion study of caffeine, methyl paraben and butyl paraben as skin–diffusing model drugs
نویسندگان
چکیده
منابع مشابه
Analytical in-house method validation for determination of permethrin (trans & cis isomers), methyl paraben, propyl paraben and BHT
Background: Permethrin is a drug used to cure pediculosis known as head lice. This drug is available in two forms: 1) permethrin topical cream 5%, 2) permethrin shampoo 1%. The aim of this study was to find a method and define the simultaneous cis and trans isomers for permethrin, methyl paraben, propyl paraben and butylated hydroxytoluene in topical cream 5% using the method high-performance l...
متن کاملButyl paraben and propyl paraben modulate bisphenol A and estradiol concentrations in female and male mice.
People are routinely exposed to the antimicrobial preservatives butyl paraben (BP) and propyl paraben (PP), as well as the monomer of polycarbonate plastics, bisphenol A (BPA). These chemicals are reliably detected in human urine and potentially interact. We investigated whether BP or PP exposure can modulate the concentrations of 14C-BPA and 17β-estradiol (E2). Female and male CF1 mice were ea...
متن کاملSTUDY PROTOCOL APMP.QM-S8 Supplementary Comparison and APMP.QM-P28 Pilot Study Determination of Mass Fraction of Benzoic Acid, Methyl Paraben and n-Butyl Paraben in Soy Sauce
Preservatives such as benzoic acid and parabens are being tested on a regular basis by regulatory authorities and food testing laboratories as they are widely found in condiments and beverages such as fruit juices, sports drinks and soft drinks. The consumption of excessive amount of preservatives can lead to adverse health effects such as allergy. Also, the levels of these preservatives in foo...
متن کاملHigher levels of ethyl paraben and butyl paraben in rat amniotic fluid than in maternal plasma after subcutaneous administration.
Parabens are a group of antimicrobial preservatives widely used in cosmetics, pharmaceuticals, and in foods. Previous in vitro and in vivo studies have shown weak estrogenic effects of some parabens. Thus, especially, exposure of fetus and infants via the mother is a matter of concern. In order to obtain more knowledge about the distribution of ethyl paraben and butyl paraben in pregnant rats a...
متن کاملThe Paraben Debate
This toxicology update reviews research over the past four years since publication in 2004 of the 1⁄4rst measurement of intact esters of p-hydroxybenzoic acid (parabens) in human breast cancer tissues, and the suggestion that their presence in the human body might originate from topical application of bodycare cosmetics. The presence of intact paraben esters in human body tissues has now been c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2021
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0247879